Two championship rodeo partners travel to New York to find their missing friend, Nacho Salazar who went missing there.

When a freighter is viciously attacked in the Pacific Ocean, a team of experts — including biologist Niko Tatopoulos and scientists Elsie Chapman and Mendel Craven — concludes that an oversized reptile is the culprit. Before long, the giant lizard is loose in Manhattan, destroying everything within its reach. The team chases the monster to Madison Square Garden, where a brutal battle ensues.

When guardian angel Seth — who invisibly watches over the citizens of Los Angeles — becomes captivated by Maggie, a strong-willed heart surgeon, he ponders trading in his pure, otherworldly existence for a mortal life with his beloved. The couple embarks on a tender but forbidden romance spanning heaven and Earth.