After the 1860s Wild West, a group of misfit settlers – including ex-doctor Phil Taylor, prostitute Belle, and homosexual bookseller Julian – decide they cannot live in their current situation in the west. They hire a grizzled alcoholic wagon master by the name of James Harlow to take them on a journey back to their hometowns in the East.

Two troubled men face their terrible destinies and events of their past as they join together on a mission to find the Holy Grail and thus to save themselves.