After a cavalry group is massacred by the Cheyenne, only two survivors remain: Honus, a naive private devoted to his duty, and Cresta, a young woman who had lived with the Cheyenne two years and whose sympathies lie more with them than with the US government. Together, they must try to reach the cavalry’s main base camp. As they travel onward, Honus is torn between his growing affection for Cresta.

While crossing the desert, a frontier scout, Jess Remsberg (Garner), rescues Ellen Grange (Andersson) from a pursuing band of Apaches, and returns her to her husband, Willard Grange (Weaver). He is contracted to act as a scout for an Army cavalry unit. Willard, Ellen, and her infant son are along for the ride, as is horse trader Toller (Poitier), a veteran of the 10th Cavalry (the “Buffalo Soldiers”). The party is trapped in a canyon by Chata, an Apache chief and grandfather of Ellen’s baby. Willard is captured and tortured. Jess sneaks away and brings reinforcements just in time to save the day. Jess learns that the man he has been hunting is none other than Willard Grange.