An ordinary word processor has the worst night of his life after he agrees to visit a girl in Soho whom he met that evening at a coffee shop.

Roberta is a bored suburban housewife who is fascinated with a woman, Susan, she only knows about by reading messages to and from her in the personals section of the newspaper. This fascination reaches a peak when an ad with the headline “Desperately Seeking Susan” proposes a rendezvous. Roberta goes too, and in a series of events involving amnesia and mistaken identity, steps into Susan’s life.

After leading his football team to 15 winning seasons, coach Bill Yoast is demoted and replaced by Herman Boone – tough, opinionated and as different from the beloved Yoast as he could be. The two men learn to overcome their differences and turn a group of hostile young men into true champions.